Abstract--Accurate prediction of Drug-T arget Affinity (DT A) is crucial for reducing experimental costs and accelerating early screening in computational drug discovery. While sequence-based deep learning methods avoid reliance on costly 3D structures, they still overlook simultaneous modeling of global sequence semantic features and local topological structural features within drugs and proteins, and represent drugs as flat sequences without atomic-level, substructural-level, and molecular-level multi-scale features. We propose HiF-DT A, a hierarchical network that adopts a dual-pathway strategy to extract both global sequence semantic and local topological features from drug and protein sequences, and models drugs multi-scale to learn atomic, substructural, and molecular representations fused via a multi-scale bilinear attention module. Experiments on Davis, KIBA, and Metz datasets show HiF-DT A outperforms state-of-the-art baselines, with ablations confirming the importance of global-local extraction and multi-scale fusion. Accurate prediction of drug-target affinity (DT A) is essential for drug screening, immune modulation and precision medicine.

Abstract--This paper presents a control framework designed to enhance the stability and robustness of legged robots in the presence of uncertainties, including model uncertainties, external disturbances, and faults. The framework enables the full-state feedback estimator to estimate and compensate for uncertainties in the whole-body dynamics of the legged robots. First, we propose a novel moving horizon extended state observer (MH-ESO) to estimate uncertainties and mitigate noise in legged systems, which can be integrated into the framework for disturbance compensation. Second, we introduce a three-level whole-body disturbance rejection control framework (T -WB-DRC). Unlike the previous two-level approach, this three-level framework considers both the plan based on whole-body dynamics without uncertainties and the plan based on dynamics with uncertainties, significantly improving payload transportation, external disturbance rejection, and fault tolerance. Third, simulations of both humanoid and quadruped robots in the Gazebo simulator demonstrate the effectiveness and versatility of T -WB-DRC. Note to Practitioners--This paper presents a practical control framework to significantly improve the robustness of legged robots against real-world uncertainties like unknown payloads, external pushes, and actuator faults. Its core is a novel three-level whole-body controller (T -WB-DRC) that uses a moving horizon estimator (MH-ESO) to accurately identify and compensate for disturbances in real-time. This dual-planning approach, which considers both ideal and disturbance-injected dynamics, outperforms previous methods. The framework's effectiveness in enhancing stability under disturbances has been successfully validated through extensive simulations and physical experiments on a quadruped robot.

With growing demands for privacy protection, security, and legal compliance (e.g., GDPR), machine unlearning has emerged as a critical technique for ensuring the controllability and regulatory alignment of machine learning models. However, a fundamental challenge in this field lies in effectively verifying whether unlearning operations have been successfully and thoroughly executed. Despite a growing body of work on unlearning techniques, verification methodologies remain comparatively underexplored and often fragmented. Existing approaches lack a unified taxonomy and a systematic framework for evaluation. To bridge this gap, this paper presents the first structured survey of machine unlearning verification methods. We propose a taxonomy that organizes current techniques into two principal categories -- behavioral verification and parametric verification -- based on the type of evidence used to assess unlearning fidelity. We examine representative methods within each category, analyze their underlying assumptions, strengths, and limitations, and identify potential vulnerabilities in practical deployment. In closing, we articulate a set of open problems in current verification research, aiming to provide a foundation for developing more robust, efficient, and theoretically grounded unlearning verification mechanisms.

--Learning grinding skills from human craftsmen by imitation learning has emerged as a prominent research topic in the field of robotic machining. Given their robust trajectory generalization ability and resilience to various external disturbances and environmental changes, Dynamical Movement Primitives (DMPs) provide a promising skills learning solution for the robotic grinding. However, challenges arise when directly applying DMPs to grinding tasks, including low orientation accuracy, inaccurate synchronization of position, orientation, and force, and the inability to generalize surface trajectories. T o address these issues, this paper proposes a robotic grinding skills learning method based on geodesic length DMPs (Geo-DMPs). First, a normalized two-dimensional weighted Gaussian kernel function and intrinsic mean clustering algorithm are proposed to extract surface geometric features from multiple demonstration trajectories. Then, an orientation manifold distance metric is introduced to exclude the time factor from the classical orientation DMPs, thereby constructing Geo-DMPs for the orientation learning to improve the orientation trajectory generation accuracy. On this basis, a synchronization encoding framework for position, orientation, and force skills is established, using a phase function related to geodesic length. This framework enables the generation of robotic grinding actions between any two points on the surface. Finally, experiments on robotic chamfer grinding and free-form surface grinding demonstrate that the proposed method exhibits high geometric accuracy and good generalization capabilities in encoding and generating grinding skills. This method holds significant implications for learning and promoting robotic grinding skills. T o the best of our knowledge, this may be the first attempt to use DMPs to generate grinding skills for position, orientation, and force on model-free surfaces, thereby presenting a novel approach to robotic grinding skills learning.

The second paradigm involves LLM agents developed using frameworks like LangChain [16], AutoGPT [11], Langroid [18], AutoGen [23], and LlamaIndex [22], which offer greater programmability and modularity, allowing developers to build sophisticated, multi-agent systems that integrate external tools and dynamic workflows [20]. Despite their advantages, both paradigms remain architecturally fragmented and lack standardized interoperability, leading to redundant development efforts and constrained scalability. From a software engineering (SE) perspective, current LLM application paradigms resemble traditional platform-centric software ecosystems, where applications are tightly coupled to proprietary APIs and execution environments. LLM app stores, while lowering the barrier to entry, impose constraints on extensibility and cross-platform interoperability, leading to vendor lock-in and duplicated development efforts across different ecosystems. In contrast, agent-based LLM frameworks provide modularity but lack standardized mechanisms for component reuse and integration, making it challenging to compose LLM applications that seamlessly operate across heterogeneous environments. This fragmentation mirrors historical challenges in SE, where monolithic architectures have given way to service-oriented and microservices-based designs to improve reusability, scalability, and maintainability. Another key limitation of existing LLM applications is inefficient hardware utilization.

Drug-target interaction is fundamental in understanding how drugs affect biological systems, and accurately predicting drug-target affinity (DTA) is vital for drug discovery. Recently, deep learning methods have emerged as a significant approach for estimating the binding strength between drugs and target proteins. However, existing methods simply utilize the drug's local information from molecular topology rather than global information. Additionally, the features of drugs and proteins are usually fused with a simple concatenation operation, limiting their effectiveness. To address these challenges, we proposed ViDTA, an enhanced DTA prediction framework. We introduce virtual nodes into the Graph Neural Network (GNN)-based drug feature extraction network, which acts as a global memory to exchange messages more efficiently. By incorporating virtual graph nodes, we seamlessly integrate local and global features of drug molecular structures, expanding the GNN's receptive field. Additionally, we propose an attention-based linear feature fusion network for better capturing the interaction information between drugs and proteins. Experimental results evaluated on various benchmarks including Davis, Metz, and KIBA demonstrate that our proposed ViDTA outperforms the state-of-the-art baselines.

In surface defect detection, due to the extreme imbalance in the number of positive and negative samples, positive-samples-based anomaly detection methods have received more and more attention. Specifically, reconstruction-based methods are the most popular. However, existing methods are either difficult to repair abnormal foregrounds or reconstruct clear backgrounds. Therefore, we propose a clear memory-augmented auto-encoder (CMA-AE). At first, we propose a novel clear memory-augmented module (CMAM), which combines the encoding and memoryencoding in a way of forgetting and inputting, thereby repairing abnormal foregrounds and preserving clear backgrounds. Secondly, a general artificial anomaly generation algorithm (GAAGA) is proposed to simulate anomalies that are as realistic and feature-rich as possible. At last, we propose a novel multi scale feature residual detection method (MSFR) for defect segmentation, which makes the defect location more accurate. Extensive comparison experiments demonstrate that CMA-AE achieves state-of-the-art detection accuracy and shows great potential in industrial applications.

TOR (The Onion Router) network is a widely used open source anonymous communication tool, the abuse of TOR makes it difficult to monitor the proliferation of online crimes such as to access criminal websites. Most existing approches for TOR network de-anonymization heavily rely on manually extracted features resulting in time consuming and poor performance. To tackle the shortcomings, this paper proposes a neural representation learning approach to recognize website fingerprint based on classification algorithm. We constructed a new website fingerprinting attack model based on convolutional neural network (CNN) with dilation and causal convolution, which can improve the perception field of CNN as well as capture the sequential characteristic of input data. Experiments on three mainstream public datasets show that the proposed model is robust and effective for the website fingerprint classification and improves the accuracy by 12.21% compared with the state-of-the-art methods.

Session 3A: Deep Learning and Adversarial ML - 02 VulDeePecker: A Deep Learning-Based System for Vulnerability Detection SUMMARY The automatic detection of software vulnerabilities is an important research problem. However, existing solutions to this problem rely on human experts to define features and often miss many vulnerabilities (i.e., incurring high false negative rate). In this paper, we initiate the study of using deep learning-based vulnerability detection to relieve human experts from the tedious and subjective task of manually defining features. Since deep learning is motivated to deal with problems that are very different from the problem of vulnerability detection, we need some guiding principles for applying deep learning to vulnerability detection. In particular, we need to find representations of software programs that are suitable for deep learning.